Rumen-preserved lysine may promote uterine health

“Increasing intestinal lysine availability during transition improved several markers of uterine health”Phil Cardoso, associate professor of animal science at the University of Illinois at Urbana-Champaign, found the team.

Published in a research journal Journal of Dairy Science..

Feeding rumen-protected methionine as a non-essential amino acid source has been shown to improve reproductive performance in lactating cows, but the effects of rumen-protected lysine (RPL) feeding during the peripartum period on reproductive performance have not been well studied. .

The authors said they sought to determine the effects of RPL feeding prenatally, postpartum, or both on follicular dynamics, uterine health, and endometrial mRNA gene expression.

Uterine infection is common in the postpartum period and can have a detrimental effect on ovarian and uterine function, the authors note.

Improving immune function and reducing the risk of inflammatory diseases of the reproductive system may lead to better reproductive outcomes, they said.

“Uterine infections can also be detrimental to ovarian regeneration because inflammation can affect the growth and function of the first dominant follicle (DF) through the neuroendocrine mechanisms of inhibiting hypothalamic GnRH release and pituitary LH secretion. .

“Furthermore, there is evidence of localized inflammatory mediators directly acting on the ovary by suppressing estradiol secretion and reducing follicular growth rate, resulting from bacterial contamination of the uterus after parturition. .

“Furthermore, chronic inflammation may result in disruption of uterine repair processes in the early postpartum period, potentially altering uterine functional capacity and future reproductive performance..

“Therefore, ovarian regeneration may benefit from modulation of the uterine immune response through nutritional strategies.”.

However, the effects of RPL feeding on reproductive tract physiology and immune response are still lacking, the paper reads.

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